Publications | Godula Lab at UCSD

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GODULA LAB

40. Biologically Derived Neoprotoglycans for Profiling Protein-Glycosaminoglycan Interactions

Ryan N. Porell, Julianna L. Follmar, Sean C. Purcell, Bryce Timm, Logan K. Laubach, David Kozirovskiy, Bryan E. Thacker, Charles A. Glass, Philip L.S.M. Gordts, Kamil Godula

ACS Chemical Biology. 2022. doi.org/10.1021/acschembio.2c00205

Porell et al 2022.jpeg

39. Cell surface photoengineering enables modeling of glycocalyx shedding dynamics

Sean C. Purcell, Michelle H. Zhang, Daniel J. Honigfort, Hans Jefferson C. Ng, Austen L. Michalak, Kamil Godula

Chemical Science. 2022. doi.org/10.1039/D2SC00524G

Purcell et al. 2022.jpeg

38. PABP1 Drives the Selective Translation of Influenza A Virus mRNA

Cyrus M.de Rozières, Alberto Pequeno, Shandy Shahabi, Taryn M. Lucas, Kamil Godula, Gourisankar Ghosh, Simpson Joseph

Journal of Molecular Biology. 2022. doi.org/10.1016/j.jmb.2022.167460

37. Stem Cell Microarrays for Assessing Growth Factor Signaling in Engineered Glycan Microenvironments

Austen L. Michalak, Greg W. Trieger, Kelsey A. Trieger, Kamil Godula

Advanced Healthcare Materials. 2022. doi.org/10.1002/adhm.202101232

Michalak_trieger_stemcellmicroarrays.tif

36. Glycocalyx crowding with synthetic mucin mimetics strengthens interactions between soluble and virus-associated lectins and cell surface glycan receptors

Daniel J. Honigfort, Meghan O. Altman, Pascal Gagneux, Kamil Godula

PNAS, 2021. doi.org/10.1073/pnas.2107896118

Honigfort_altman_glycocaylx_crowding.tif

35. Mucin-mimetic glycan arrays integrating machine learning for analyzing receptor pattern recognition by influenza A viruses

Taryn M. Lucas, Chitrak Gupta, Meghan O. Altman, Emi Sanchez, Matthew R. Naticchia, Pascal Gagneux, Abhishek Singharoy, Kamil Godula

Chem. 2021 doi.org/10.1016/j.chempr.2021.09.015

Taryn Lucas_machinelarningarrays.tif

34. Genome-wide screens uncover KDM2B as a modified of protein binding to heparan sulfate

Ryan J. Weiss, Philipp N. Spahn, Austen W.T. Chiang, Qing Liu, Jing Li, Kristina M. Hamill. Sandra Rother, Thomas M. Clausen, Marten A. Hoeksema, Bryce M. Timm, Kamil Godula, Christopher K. Glass, Yitzhak Tor, Philip L. S. M. Gordts, Nathan E. Lewis, Jeffrey D. Esko.

Nature Chemical Biology. 2020. doi.org/10.1038/s41589-021-00776-9

Bryce_weiss_KDM2B_fig1_full.tif

Bryce_weiss_KDM2B_fig1_full.tif

33. Spatially Controlled Glycocalyx Engineering for Growth Factor Patterning in Embryoid Bodies

Matthew R. Naticchia, Logan K. Laubach, Honigfort Daniel J., Purcell Sean C., Kamil Godula

Biomaterials Science. 2020. doi.org/10.1039/D0BM01434F

LL_MN_paper_TOC_image.tiff.tif

32. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Chelsea D. Painter, Bryan E. Thacker, Charles A. Glass, Anoop Narayanan, Sydney A. Majowicz, Yang Zhang, Jonathan L. Torres, Gregory J. Golden, Ryan Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sandra L. Leibel, Summit K. Chanda, Aaron G. Schmidt, Kamil Godula, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko

Cell. 2020. doi.org/10.1016/j.cell.2020.09.033

SAR_cov_TOC_image_ALM_made.tif

31. Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

Honigfort D, Zhang M, Verespy S, Godula K

RSC Faraday Discuss. 2019. doi.org/10.1039/C9FD00024K

30. Synthetic glycoscapes: addressing the structural and functional complexity of the glycocalyx

Purcell SC, Godula K

Royal Soc. Chem. 2019. doi.org/10.1098/rsfs.2018.0080

29. Efficient Synthesis of Heparinoid Bioconjugates for Tailoring FGF2 Activity at the Stem Cell–Matrix Interface

Trieger GW, Verespy S, Gordts PLSM, Godula K

Bioconjugate Chem. 2019. doi.org/10.1021/acs.bioconjchem.8b00921

Screen Shot 2019-03-06 at 2.20.16 PM.png

28. Influencing Early Stages of Neuromuscular Junction Formation through Glycocalyx Engineering

Huang ML, Tota EM, Lucas TM, Godula K.

ACS Chem Neuro. 2018. doi.org/10.1021/acschemneuro.8b00295

ACS Chem Neuro Fig.gif

27. Embryonic Stem Cell Engineering with a Glycomimetic FGF2/BMP4 Co-Receptor Drives Mesodermal Differentiation in a Three-Dimensional Culture

Naticchia MR, Laubach LL, Tota EM, Lucas TM, Huang ML, Godula K.

ACS Chem Bio. 2018. doi.org/10.1021/acschembio.8b00436

ACS Chem Bio Fig.gif

26. Following sugar patterns in search of galectin function

PNAS. 2018. doi.org/10.1073/pnas.1801039115

25. Heparin-fibronectin interactions in the development of extracellular matrix insolubility

Raitman I, Huang ML, Williams SA, Friedman B, Godula K, Schwarzbauer JE.

Matrix Biol. 2017. doi:10.1016/j.matbio.2017.11.012

24. Small molecule antagonist of cell surface glycosaminoglycans restricts mouse embryonic stem cells in a pluripotent State

Huang ML, Michalak AL, Fisher CJ, Christy M, Smith RAA, Godula K.

Stem Cells. 2017. doi:10.1002/stem.2714

23. Glycocalyx scaffolding with synthetic nanoscale glycomaterials

Huang ML, Purcell SC, Verespy S, Wang Y, Godula K.

Biomater Sci. 2017. doi: 10.1039/C7BM00289K

22. Human milk oligosaccharides inhibit growth of group B Streptococcus

Lin AE, Autran CA, Szyszka A, Escajadillo T, Huang ML, Godula K, Prudden AR, Boons G, Lewis AL, Doran KS, Nizet V, Bode L.

J Biol Chem. 2017. doi: 10.1074/jbc.M117.789974.

21. Synthetic mucus nanobarriers for identification of glycan-dependent primary Influenza A infection inhibitors

Cohen MC, Senaati HP, Fisher CJ, Huang ML, Gagneux P, Godula K.

ACS Central Science. 2016. 2: 710-714.

20. Glycomaterials for probing host–pathogen interactions and the immune response

Huang ML, Fisher CJ, Godula K.

Experimental Biology and Medicine. 2016. 241: 1042-1053.

19. Capture and characterization of influenza A virus from primary samples using glycan bead arrays

Cohen M, Fisher CJ, Huang ML, Lindsay LL, Plancarte M, Boyce WM, Godula K, Gagneux P.

Virology. 2016. 493: 128-135.

18. Nanoscale materials for probing the biological functions of the glycocalyx

Huang ML, Godula K.

Glycobiology. 2016. 26: 797-803.

17. Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays

Huang ML, Cohen M, Fisher CJ, Schooley RT, Gagneux P, Godula K.
Chem. Commun. 2015 Dec 31;51:5326-9. doi:10.1039/C4CC08613A

Selected as part of the Chemical Communications 2015 Emerging Investigators Issue

16. Priming the cellular glycocalyx for neural development

Huang ML and Godula K.

ACS Chem Neurosci. 2014 Oct 15;5(10):873-5. doi: 10.1021/cn500194b

1 5. Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in em bryonic stem cells

Huang ML, Smith RAA, Trieger GW, Godula K.
J Am Chem Soc. 2014 Jul 30;136(30):10565-8. doi: 10.1021/ja505012a.

Check out the C&EN highlight here.

14. The cancer glycocalyx mechanically primes integrin-mediated growth and survival

Paszek, MJ, DuFort, CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver VM.
Nature. 2014 Jul 17;511(7509):319-25. doi: 10.1038/nature13535.

13. Chemoenzymatic Fc Glycosylation via Engineered Aldehyde Tags

Smith EL, Giddens JP, Iavarone AT, Godula K, Wang L-X, Bertozzi C.
Bioconjugate Chem. 2014 Apr 16;25(4):788-95. doi: 10.1021/bc500061s.

12. Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers

Mauris J, Mantelli F, Woodward AM, Cao Z, Bertozzi CR, Panjwani N, Godula K, Argueso P.
PLoS ONE. 2013 Aug 19;8(8):e72304. doi:10.1371/journal.pone.0072304

11. Density variant glycan microarray for evaluating cross-linking of mucin-like glycoconjugates by lectins

Godula K, Bertozzi CR.
J Am Chem Soc. 2012 Sep 26;134(38):15732-42.

10. Synthesis of glycopolymers for microarray applications via ligation of reducing sugars to a poly(acryloyl hydrazide) scaffold

Godula K, Bertozzi CR.
J Am Chem Soc. 2010 Jul 28;132(29):9963-5.

9. Control of the molecular orientation of membrane-anchored biomimetic glycopolymers

Godula K, Umbel ML, Rabuka D, Botyanszki Z, Bertozzi CR, Parthasarathy R.
J Am Chem Soc. 2009 Jul 29;131(29):10263-8.

8. Synthesis and microcontact printing of dual end-functionalized mucin-like glycopolymers for microarray applications

Godula K, Rabuka D, Nam KT, Bertozzi CR.
Angew Chem Int Ed Engl. 2009;48(27):4973-6.

Publications from graduate and undergraduate work:

7. Expeditious synthesis of contorted hexabenzocoronenes.

Plunkett KN, Godula K, Nuckolls C, Tremblay N, Whalley AC, Xiao S.
Org Lett. 2009 Jun 4;11(11):2225-8.

6. C-H bond functionalization in complex organic synthesis.

Godula K, Sames D.
Science. 2006 Apr 7;312(5770):67-72.

5. Site-specific phenylation of pyridine catalyzed by phosphido-bridged ruthenium dimer complexes: a prototype for C-H arylation of electron-deficient heteroarenes.

Godula K, Sezen B, Sames D.
J Am Chem Soc. 2005 Mar 23;127(11):3648-9.
Erratum: J Am Chem Soc. 2006 Mar 8;128(9):3102.

4. Iron-mediated preparation of vinylcyclopropanecarboxylates: scope, mechanism, and applications.

Yun YK, Godula K, Cao Y, Donaldson WA.
J Org Chem. 2003 Feb 7;68(3):901-10.

3. C-C bond formation via C-H bond activation: synthesis of the core of teleocidin B4.

Dangel BD, Godula K, Youn SW, Sezen B, Sames D.
J Am Chem Soc. 2002 Oct 9;124(40):11856-7.

2. A simple and efficient synthesis of optically pure tricarbonyl(methyl 6-oxo-2,4-hexadienoate)iron.

Godula K, Bärmann H, Donaldson WA.
J Org Chem. 2001 May 18;66(10):3590-2.

1. Synthesis of Cyclopropanes via Organoiron Methodology: Preparation of 2-(2'-carboxy-3'-ethylcyclopropyl)glycine.

Godula K, Donaldson WA.
Tet Lett. 2001 Jan 8;42(2):153-4.

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